Baker Heart and Diabetes Institute;Monash University
发明人:
Ritchie, Rebecca Helen,Qin, Cheng Xue,Christopoulos, Arthur,Sexton, Patrick Michael,Baell, Jonathan Bayldon
申请号：
AU2016214975
公开号：
AU2016214975A1
申请日:
2016.02.04
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention relates generally to a method of therapeutically or prophylactically treating ischaemia-induced myocardial tissue damage, in particular ischaemia-reperfusion-induced myocardial tissue damage. More particularly, the present invention relates to a method of reducing the extent of ischaemia-induced myocardial tissue damage in a mammal by selectively upregulating FPRl-mediated ERK signalling. The method of the present invention is useful, inter alia, in reducing the extent and/or severity of myocardial tissue damage associated with conditions characterised by myocardial ischaemia or myocardial ischaemia and reperfusion, such as acute myocardial infarction caused by atherosclerotic artery occlusion or blood clot-induced artery occlusion.
