НЬЮ ЙОРК ЮНИВЕРСИТИ;ДЗЕ ГАВЕРМЕНТ ОФ ДЗЕ ЮНАЙТЕД СТЕЙТС ОФ АМЕРИКА ЭЗ РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТЭРИ ОФ ДЗЕ ДЕПАРТМЕНТ ОФ ХЕЛТ ЭНД ХЬЮМЭН СЕРВИСИЗ;НЬЮ ЙОРК ЮНИВЕРСИТИ
1. A method for preventing, treating or alleviating in a mammal a disease or condition that is associated with RORγt in vivo activity, comprising administering to the mammal an amount effective for treating the disease or condition of an amount of a compound of formula I: or a pharmaceutically acceptable salt, solvate or prodrug thereof； or stereoisomers thereof, of isotropic variants and tautomers； where each Cy and Cy is independently selected from substituted or unsubstituted aryl and heteroaryl； each n1 and n2 are independently 1, 2, 3, 4 or 5； each R and R independently represent oh H, substituted or unsubstituted C-alkyl or CN； or R and R are connected to form a cycloalkyl ring； R is H, substituted or unsubstituted C-C1-6alkyl or aryl； or one of R and R is attached to the C atom in the CR group to form a cyclopropyl ring； or R is attached to the C atom in the CRR group to form a cyclopropyl ring； each R and R are independently selected from H, OH, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio , substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, substituted or unsubstituted amino group, substituted or unsubstituted arylalkyl, sulfo, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted sulfanyl, substituted or unsubstituted amino sulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted arylsulfonyl, azido, substituted or unsubstituted carbamoyl1. Способ предотвращения, лечения или облегчения у млекопитающего заболевания или состояния, которое связано с активностью RORγt in vivo, включающий введение млекопитающему эффективного для лечения заболевания или состояния количества соединения формулы I:или его фармацевтически приемлемой соли, сольвата или пролекарства；или его стереоизомеров, изотропных вар
