UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;UNIVERSITY OF FLORIDA RESEARCH FOUNDATION;TORREY PINES INSTITUTE FOR MOLECULAR STUDIES; INC.
发明人:
COGLE, CHRISTOPHER R.,MEACHAM, AMY M.,SAYESKI, PETER P.,GIULIANOTTI, MARCELLO A.,HOUGHTEN, RICHARD A.,WELMARKER, GREGORY S.
申请号：
CA3001882
公开号：
CA3001882A1
申请日:
2016.11.04
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Cancer is a disease for which there remains a great unmet medical need, and therefore the discovery and development of new antineoplastic agents is critically important. The present invention relates in part to new therapeutic compounds with antineoplastic activity. Provided herein are polyamine sulfonamides such as compounds of Formula (I), or pharmaceutically acceptable salts thereof, which may be used in the treatment and/or prevention of diseases such as cancer. Also provided herein are pharmaceutical compositions and kits comprising the inventive compounds. Furthermore, the present invention provides methods of treating and/or preventing diseases (e.g., cancer) using compounds of Formula (I), or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof. Other methods provided include methods for inducing apoptosis of a cell, as well as methods for inhibiting alpha-enolase enzymatic activity in vivo and in vitro.
