The Trustees of Dartmouth College;King's College London
发明人:
Noelle, Randolph J.,Ceeraz, Sabrina,Lemercier, Isabelle,Nowak, Elizabeth,Lines, Janet Louise
申请号:
AU2013277051
公开号:
AU2013277051B2
申请日:
2013.06.21
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V- domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (