Disclosed is a novel composition which has a function of stimulating production of laminin-332. The composition is stable and safe, and can be used routinely. Specifically disclosed is a laminin-332 production stimulating composition which contains one or more compounds selected from the group consisting of D-alanine, D-hydroxyproline, derivatives and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving a skin condition. The skin condition may include, but is not limited to a photoaging, wrinkles, a rough skin, fine wrinkles and a dry skin. The composition may be used for an external preparation for the skin or a food.本發明開發一種組合物，其係具有促進層黏連蛋白332產生之作用的新穎組合物，並且可用於日常生活中，穩定且安全。本發明提供一種包含選自由D-丙胺酸及D-羥基脯胺酸、與其衍生物及/或鹽所組成之群中之1種或2種以上的化合物之層黏連蛋白332產生促進組合物。有時用於抑制及/或改善皮膚狀態。上述皮膚狀態包括光老化、皺紋、肌膚粗糙、細紋及乾燥，但並不限定於該等。上述組合物有時用作皮膚外用劑或食品。
