Yuhong L. Ning,Weiming Xu,Rajesh Chopra,Peter Worland,Shuichan Xu
申请号：
US13701224
公开号：
US20130158023A1
申请日:
2012.08.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided herein are methods for predicting the LKB1 status of a patient or a biological sample, comprising the measurement of particular gene expression levels relative to a set of reference levels that represent the gene expression level of a biological wild-type sample without LKB1 gene or protein loss or mutation and the gene expression level of a reference sample with LKB1 gene or protein loss or mutation. Further provided herein are methods for treating and/or preventing a cancer or a tumor syndrome in a patient, comprising administering an effective amount of a TOR kinase inhibitor to a patient having cancer or a tumor syndrome, characterized by particular gene expression levels.
