PME-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and gene silencing of PME-1 to inhibit epithelial to mesenchymal transition
Lyndi Rice,Michelle Pusey,Ewa Wandzioch,Sophie Marie Genevieve Bail,Amy Lynn Werda
申请号：
US14263085
公开号：
US09657349B2
申请日:
2014.04.28
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are methods of attenuating activity of the PME-1 gene. siRNAs or shRNAs are used to target against PME-1, thereby reducing the PME-1 mRNA. It is disclosed that the siRNAs or shRNAs targeted against PME-1 attenuate the epithelial to mesenchymal transition, thereby inhibit endometrial cancer development. A kit containing siRNA or shRNA reagents for attenuating the PME-1 gene expression is also disclosed.
