A system for fulfilling peer-to-peer transactions by autonomous robot vehicles includes processor(s) and a memory storing instructions which, when executed by the processor(s), cause the system to: receive information on a peer-to-peer transaction between a seller and a buyer for an item, communicate instructions to an autonomous vehicle to travel to a first destination and receive the item, receive an indication that the item has been received, communicate instructions to the autonomous vehicle to travel to a second destination to deliver the item to the buyer, receive a signal indicating that buyer funds are in escrow, and receive a signal indicating that the item is accepted or rejected by the buyer. In a case where the item is accepted, the system communicates a release of the funds from the escrow to the seller. In a case the item is rejected, the system determines a handling itinerary for the item.