UNIVERSITE DE MONTREAL;BRISTOL-MYERS SQUIBB COMPANY
发明人:
ROGER REMILLARD,ELDON SCOTT PRIESTLEY,JULIA GUY,LAURENCE DUBE,MICHAEL KORNACKER,EDWARD H. RUEDIGER,DANIEL H. DEON,DOUGLAS JAMES RIEXINGER,PANCRAS C. WONG,CLAUDIO MAPELLI,BRAD D. MAXWELL,MARC GAGNON,JA
申请号：
ARP130101380
公开号：
AR090834A1
申请日:
2013.04.24
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. Requirement 1: a compound (1) with formula characteristics,O stereoisomer, a Taurus, a pharmaceutically acceptable salt, or a solution or dopant in which w is or s, r830404 is R1 or r74191；This is s-cr831222 = cr831393 -；R¹ is independently selected from the group consisting of: halo, C₁₋₄ alkyl,C₂₋₃ alkenyl,1. C83228331 asphalt；C₃₋₄ cycloalkyl,C₁₋₄ alkoxy,C₁₋₂ alkoxy-C₁₋₂ alkyl,tetrahydrofuran-2-yl； Cilt alkylthio,C₁₋₄NH- alkyl,(Alquil C) N-halo-C₁₋₂ alkyl,a. Containing 1 to 5 halogens, f or Cl halogens, c833238331 halogens；C₁₋₂ haloalkoxy,a. Halogen asphalt c8321c833183222；R¹ᵃ is independently selected from the group consisting of: H, halo, C₁₋₄ alkyl,C₂₋₃ alkenyl,1. C83228331 asphalt；C₃₋₄ cycloalkyl,C₁₋₄ alkoxy,C₁₋₂ alkoxy-C₁₋₂ alkyl,tetrahydrofuran-2-yl； Cilt alkylthio,C₁₋₄NH- alkyl,(Alquil C) N-halo-C₁₋₂ alkyl,a. Containing 1 to 5 halogens, f or Cl halogens, c833238331 halogens；C₁₋₂ haloalkoxy,a. Halogen asphalt c8321c833183222；R831222 and r831393 are independent of a group of coking layers h, halo and c83218331；C₁₋₄ alkoxy,halo-C₁₋₂ alkyl,C₁₋₂ haloalkoxy,Cn, and oh, if there is at least one r7491,R⁸ and R⁹ is not H； R² is selected from the group consisting of: H, halo, C₁₋₄ alkyl,C₁₋₄ alkoxy,Y Ciano； X1 was selected from CH, n or cr183044 groups；X2,X³ and X⁴ are independently selected from CR³ or N； R³ is selected from the group consisting of H, C₁₋₄ alkyl,C₂₋₄ alkenyl,1. C 83228331 asphalt；C₁₋₄ alkoxy,Cilt alkylthio,Halo, oh, CN, ocf8323,OCHF₂,OCH F alcoxi C -alcoxi Chalo-C₁₋₃ alkyl,containing 1 to 5 halogens, benzyloxy substituted with 0 to 3 groups independently selected from the group consisting of halo, C₁₋₄ alkoxy,1. Lease of c83218331 and 83242431；Bicycle, cf832323,OCF83223,Five or six members of the alien, ha ha, ochf832222,di-C₁₋₄amino and cyano alkyl, and - (CH₂) ₙ₁-phenyl substituted with 0 to 3 groups independently selected from the group consisting of halo, C₁₋₄ alkoxy,1. Lease of c83218331 and 83242431；Bicycle, cf832323,OCF83223,Five or six me
