Baudry, Michel,Bi, Xiaoning,Standley, Steve,Luo, Lyna,Wang, Yubin,Zhu, Guoqi,Briz, Victor
申请号：
AU2015346371
公开号：
AU2015346371A1
申请日:
2015.11.11
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Molecules that selectively inhibit or stimulate the activity of isoforms of calpains are presented. Methods for screening and characterizing such molecules are also presented. Specific functions of calpain-1 calpain-2 in long term potentiation (LTP), learning and memory, neurodegeneration and diseases of synaptic dysfunction are characterized using novel calpain inhibitors, substrates and related methods. The compounds, compositions, and methods described herein are expected to be useful, for treating neurodegenerative diseases and other diseases of synaptic function, and for modulating cognition in patients in need thereof.
