USE OF RANK/RANKL ANTAGONISTS FOR TREATING NEUROMUSCULAR DISORDERS, GENETIC MYOPATHIES AND/OR NON GENETIC MYOPATHIES AND/OR FOR REGULATING SKELETAL AND CARDIAC MUSCLE DISUSE, DISEASES AND AGING
A pharmaceutical composition includes one or more RANK/RANKL antagonists and a pharmaceutically acceptable carrier. The composition can be used for treating neuromuscular disorders, non-genetic myopathies, or genetic myopathies； maintaining and/or preserving the excitation:contraction:relaxation coupling； reducing loss of muscle strength associated with neuromuscular disorders, non-genetic myopathies or genetic myopathies； reducing the loss of muscular strength associated with skeletal or cardiac muscle disuse, diseases and aging； or regulating skeletal or cardiac muscle disuse, diseases and/or aging in a patient in need thereof. Methods are used to identify candidate compounds.
