TOLERANCE INDUCTION OR IMMUNOSUPPRESSION TO PREVENT IN PARTICULAR GRAFT-VERSUS-HOST-DISEASE (GVHD) BY SHORT-TERM PRE-INCUBATION OF TRANSPLANTED CELL SUSPENSIONS, TISSUES OR ORGANS COATED WITH LIGANDS TO CELL SURFACE MOLECULES
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人:
Stephan Fricke,Franck Emmrich,Nadja Hilger
申请号：
EP18159086
公开号：
EP3351255A1
申请日:
2011.12.02
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains. Preferably, the specificity and mode of action of the anti-CD4 antibodies are not affected by the modification(s).
