Humanized anti CLEVER-1 antibodies and their use

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专利权人:

Faron Pharmaceuticals Oy

发明人:

Maksimow, Mikael,Jalkanen, Markku,Vainio, Marita

申请号：

AU2017252343

公开号：

AU2017252343A1

申请日:

2017.04.18

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

This invention relates to an agent and a humanized antibody or single chain Fv or Fab fragment capable of binding to human CLEVER-1 recognizing an epitope of CLEVER-1, wherein the epitope is discontinuous and comprises the sequences: PFTVLVPSVSSFSSR and QEITVTFNQFTK. This invention relates also an agent capable of binding to an epitope of human CLEVER-1 for use in removing tumour or antigen induced immunosuppression. Further, the invention relates to a pharmaceutical composition comprising the agent capable of binding to human CLEVER-1 and an appropriate excipient.

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