A portable blood sampling device comprises: a laser module a skin contact part which is disposed in the direction in which the laser radiation is emitted so that the laser radiation is locally concentrated on a region of a skin that is to be perforated a radiation port cover disposed through the laser module and across the direction in which the laser radiation is emitted a first safety switch part which switches on and off via upward and downward movement in response to opening and closing of the radiation port cover a second safety switch part which has an elastic member between the laser module and the skin contact part and switches on and off in response to pushing and pulling of the skin contact part and a button switch which allows the laser radiation to be emitted.