A pharmaceutical composition having a transcription factor decoy and a pharmaceutical acceptable carrier thereof is provided, wherein the transcription factor decoy is TCF decoy. A method for curing or preventing endotoxin-treated endothelial cells from apoptosis is provided. A method for treating or meliorating septic shock is also provided. The transcription factor decoy is effective on melioration of endothelial cell death after lipopolysaccharide challenge. Furthermore, the pharmaceutical composition is easy to be prepared, economic and has low immunogenicity.
