Connectors interfacing a mechanical circulatory system with a patients natural vasculature are provided herein. Such connectors include aortic connectors that facilitate fluid coupling of an outflow graft tube from an implanted blood pump with a patients aorta. Aortic connectors can include a substantially planar portion configured for sealed attachment with a wall of the aorta and a tubular connector portion extending from an inlet opening to an outlet opening. The substantially planar portion can include a flexible membrane for attachment to an outer surface of the aorta and/or a flange for engagement with an inner surface of the aorta. The tubular connector can extend from the substantially planar portion at a pre-determined angle and include one or more attachment features to facilitate rapid fluidly sealed attachment to the outflow graft tube.
