The invention relates to the technical field of medicine.The invention discloses a compound and method for the treatment of Trop2 positive disease. The compound is an antibody-drug conjugate (ADC).The ADC in the invention contains an anti trop2 antibody coupled with a highly cytotoxic Meideng alkaloid drug, which can specifically deliver the cytotoxin to the disease tissue. Meanwhile, the anti fucose modified antibody significantly enhances its mediated ADCC effect and synergistically enhances the anti-tumor effect of the ADC. The ADC is mainly used for targeting the treatment of human trop2 positive tumor diseases.The invention also provides the preparation of these compounds and methods for using them in the diagnosis and treatment of such as malignant tumors.本發明涉及醫藥技術領域。本發明公開了Trop2陽性疾病治療的化合物及方法，化合物爲抗體‑藥物偶聯物(ADC)。本發明中的ADC包含與強細胞毒性的美登木素生物鹼藥物偶聯的抗Trop2抗體，能特異性地將細胞毒素靶向遞送至疾病組織，同時去岩藻糖修飾的抗體顯著增強了其介導的ADCC效應，協同增強了ADC的抗腫瘤效應，ADC主要用於靶向治療人Trop2陽性的腫瘤疾病。本發明也提供了這些化合物的製備以及將其用於診斷和治療諸如惡性腫瘤的方法。
