Donde, Yariv,Burk, Robert M.,Garst, Michael E.,Nguyen, Jeremiah H.
申请号：
AU2005306656
公开号：
AU2005306656B2
申请日:
2005.11.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Disclosed herein are compounds comprising Formula (I) or a pharmaceutically acceptablesalt or a prodrug thereof, wherein a dashed line represents the presence or absenceof a bond Y is a carboxylic acid, sulfonic acid, or phosphonic acid functionalgroup or an amide or ester thereof comprising from 0 to 12 carbon atoms or Y ishydroxymethyl or an ether thereof comprising from 0 to 12 carbon atoms or Y isa tetrazolyl functional group A is -(CH)-, -CH-CH=CH-(CH)-,or -CH2-C =- C-(CH)- wherein 1 or 2 carbons may be substitutedwith S or O B is hydrogen, C hydrocarbyl, CN, , or-(CH)X(CH)H, wherein m is at least1 and the sum of m and p is from 1 to 5 X is S or O J is H, CH, or CFDis a covalent bond, CH. O, or S and E is an aromatic heterobicyclicring system which may have substituents comprising up to 6 non-hydrogen atomseach. Methods, compositions, and medicaments related thereto are also disclosed.
