APPLIED MOLECULAR TRANSPORT INC.;LIU, KEYI;MACKAY, JULIA DAWN;FENG, WEIJUN;HUNTER, THOMAS CARL
发明人:
LIU, KEYI,MACKAY, JULIA DAWN,FENG, WEIJUN,HUNTER, THOMAS CARL,MRSNY, RANDALL J.
申请号：
CA3093386
公开号：
CA3093386A1
申请日:
2019.03.08
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present disclosure relates to isolated non-naturally occurring delivery constructs comprising a bacterial toxin-derived delivery construct coupled to a biologically active therapeutic cargo； wherein the delivery construct is capable of delivering the biologically active cargo via transcytosis transport across an epithelial cell； and wherein the delivery construct does not comprise a bacterial toxin-derived translocation domain or a bacterial toxin-derived catalytic (cytotoxic) domain.
