SMEJKAL TOMAS,SMITS HELMARS,WENDEBORN SEBASTIAN VOLKER,BERTHON GUILLAUME,CASSAYRE JEROME YVES,EL QACEMI MYRIEM
申请号：
IN1767/DELNP/2014
公开号：
IN2014DN01767A
申请日:
2014.03.07
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
121212The present invention relates to processes for the enantio selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds as well as to intermedates in the processes. The processes include those comprising (a i) reacting a compound of formula (Ia) formula (Ia) wherein P is alkyl aryl or heteroaryl each optionally substituted wherein the heteroaryl is connected at P via a ring carbon atom R is chlorodifluoromethyl or trifluoromethyl R is aryl or heteroaryl each optionally substituted with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIa formula (IIa) wherein P R and R are as defined for the compound of formula (Ia) and (a ii) oxidising the compound of formula IIa with a peroxy acid or peroxide in the presence of an acid to give a compound of formula (VI) formula (VI) wherein R and R are as defined for the compound of formula (Ia).
