THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE MARINE BIOLOGICAL LABORATORY;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人:
JENNIFER R. MORGAN,GAL BITAN,DAVID J. BUSCH
申请号：
US14536176
公开号：
US20150202222A1
申请日:
2014.11.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.
