Dendritic cells effective in the prevention and curing of diseases, especially hepatitis B. Dendritic cells having HBs antigen presenting capability obtained by a process including the step of pulsing dendritic cells with HBs antigen are effective as a dendritic cell vaccine in the prevention and curing of hepatitis B. As the HBs antigen, use can be made of an HBs antigen contained in HB vaccine. Vaccine pulsed dendritic cells obtained by a process including the step of pulsing dendritic cells with a vaccine can be used as a dendritic cell vaccine in not only patients but also healthy subjects. As the vaccine for pulsing, use can be made of a wide variety of vaccines.
