The present invention relates to a composition for ameliorating a neurodegenerative disease caused by oxidative stress, which comprises maize bean-derived meiocin as an active ingredient. More specifically, the present invention relates to a composition for inhibiting neuronal cell death caused by oxidative stress by catalase, glutathione The present invention relates to a method for treating a neurodegenerative disease of the nervous system by inhibiting or inhibiting apoptosis of neurons by increasing mRNA expression of peroxidase-1, superoxide dismutase-1,2, heme oxygenase-1, Lt; / RTI >;본 발명은 옥수수수염 유래 메이신을 유효성분으로 포함하는 산화적스트레스로 인한 퇴행성 뇌신경계 질환 개선용 조성물에 관한 것으로, 보다 구체적으로는 메이신이 산화스트레스에 의한 신경세포사멸을 항산화효소들 (catalase, glutathione peroxidase-1, superoxide dismutase-1,2, heme oxygenase-1)의 mRNA 발현을 증가시켜 산화스트레스를 감소시켜주어, 궁극적으로 신경세포의 세포사멸 (apoptosis)을 억제 또는 차단함으로써 퇴행성 뇌신경계 질환 개선용 약리적 조성물을 발명한 것이다.