A method with apparatus for performing surgery using plasma is described. In one exemplary embodiment, the apparatus includes a radiofrequency signal generator, a conditioning network coupled to the radiofrequency signal generator, and a catheter coupled to the conditioning network, the catheter including at least one electrode, such that the conditioning network conditions radiofrequency energy produced by the radiofrequency signal generator to create plasma at the at least one electrode of the catheter. Such novel plasma ablation system provides the capability to create high precision ablation with minimal damage to adjacent structures in numerous types of matter while employing multiple operation platforms including catheter based plasma application.
