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Nucleic acid complex and nucleic acid delivery composition
专利权人:
大塚製薬株式会社;竹内 洋文
发明人:
竹内 洋文,戸塚 裕一,平 安幸,豊福 秀一
申请号:
JP2010517212
公开号:
JP5340282B2
申请日:
2008.11.06
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention provides a nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid to be introduced into a cell, and a highly branched cyclic dextrin. Moreover, when a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine is used as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, the efficiency of intracellular delivery, and the persistence of the nucleic acid in the cell can be further improved.
来源网站:
中国工程科技知识中心
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