A driver drowsiness prediction system includes a vital signal detection unit, a control unit and a network bridge module. The vital signal detection unit detects vital signals of a driver. The control unit receives the drivers vital signs, and stores at least a feature signal. The feature signal represents the vital signal pattern of losing consciousness. The control unit continuously compares the detected vital signal with the feature signal. When the vital signal is similar to the feature signal, the control unit issues a pre-alarming command. The network bridge module receives the pre-alarming command and is triggered to perform a network connection process. The network bridge module logs into a pre-determined social website according to a login script, and then sends a pre-alarming message thereon, wherein the pre-alarming message includes an event indicating the driver is near unconsciousness.
