BEIGHT Douglas W.,COATES David A.,JOSEPH Sajan,MCMILLEN William T.,PARTHASARATHY Saravanan,PEI Huaxing,SAWYER Jason Scott,WOLFANGEL Craig D.,ZHAO Gaiying,PEI Hu
申请号：
SI201530417
公开号：
SI3204377T1
申请日:
2015.09.30
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFβR1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.
