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AQUATIC COMPOSITION CONTAINING A FOLICULOSTIMULATING HORMONE
专利权人:
АСКА ФАРМАСЬЮТИКАЛ КО.; ЛТД. (JP)
发明人:
АСАДА Хадзиме (JP),КАТАОКА Хиросиге (JP)
申请号:
RU2011122629/15
公开号:
RU2011122629A
申请日:
2009.11.02
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. An aqueous composition comprising follicle-stimulating hormone and histidine as a stabilizing agent. The aqueous composition according to claim 1, where the concentration of histidine is from 0.05 to 10.0 mg / ml. The aqueous composition according to claim 1 or 2, which comprises a genetically recombinant human follicle-stimulating hormone as follicle-stimulating hormone. The aqueous composition according to claim 3, which further comprises one or two or more types of substances selected from the group consisting of saccharide, propylene glycol and creatinine. The aqueous composition according to claim 4, which further comprises one or more types of substances selected from the group consisting of xylitol, inositol, propylene glycol, sucrose, calcium gluconate, sodium gluconate, mannitol, macrogol 600 and creatinine. The aqueous composition according to claim 3, which further comprises methionine as a stabilizing agent. The aqueous composition according to claim 6, wherein the methionine concentration is from 0.05 to 10 mg / ml. The aqueous composition according to claim 4, which further comprises a surfactant. The aqueous composition of claim 8, wherein the surfactant is a nonionic surfactant. The aqueous composition of claim 8, which further comprises a phosphate buffer substance or citrate buffer substance. The aqueous composition of claim 10, which has a pH value of from 6.5 to 8.0.12. The aqueous composition of claim 10, which further comprises sodium chloride as a tonicity control agent. The aqueous composition of claim 12, further comprising EDTA as a polycarboxylic acid. An agent for stabilizing an aqueous pharmaceutical composition containing1. Водная композиция, включающая фолликулостимулирующий гормон и гистидин в качестве стабилизирующего средства.2. Водная композиция по п.1, где концентрация гистидина составляет от 0,05 до 10,0 мг/мл.3. Водная композиция по п.1 или 2, которая включает генетически рекомбинантный человеческий фолликулостимулирующий гор
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