The invention provides specific anti-Cathepsin G antibodies that are capable of inducing formation of anti-inflammatory macrophage. The invention also provides methods for generating anti-inflammatory macrophages. The methods involve contacting bone marrow cells or monocytes with a Cathepsin G antibody described herein, and culturing the cell mixture under conditions to allow formation of M2 macrophage. Also provided in the invention are therapeutic methods of using a pharmaceutical composition containing a Cathepsin G antibody or induced M2 macrophage described herein for treating autoimmune diseases and other disorders associated with undesired immune responses.
