Jong Hyun Cho,Steven J. Coats,Raymond F. Schinazi,Hongwang Zhang,Longhu Zhou
申请号：
US13144718
公开号：
US08609627B2
申请日:
2010.02.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.
