Orum, Henrik,Koch, Troels,Elmen, Joacim,Hansen, Henrik Frydenlund
申请号：
AU2007209481
公开号：
AU2007209481B2
申请日:
2007.01.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The current invention provides oligonucleotides which comprise a dinucleotideconsisting of a 5' locked nucleic acid (LNA), a phosphorothioate intemuclosidelinkage bond to a 3' RNA or RNA analogue. The dinucleotide reduces the strengthof hybridization of the oligonucleotide to a complementary nucleic acid target.The modification can be used to modulate hybridisation properties in both singlestranded oligonucleotides and in double stranded siRNA complexes, particularlyin oligonucleotides where the use of LNA results in excessively strong hybridisationproperties.
