LEE, KWANG-HOON,LEE, JUNE HYUNG,LEE, NA RAE,JEONG, EUNJEONG,PARK, YOUNG BONG,CHANG, NAKHO,LEE, EUN-JUNG,KIM, KI HONG,CHOI, SUNGHYUN,CHOI, BYUNG HYUN,PARK, JU YOUNG,SONG, MOO YOUNG,LEE, JONG-SEO,KIM, K
申请号：
CA3091639
公开号：
CA3091639A1
申请日:
2019.02.28
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition. The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.
