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Process for production of spherical microparticles comprising tamsulosin hydrochloride
专利权人:
Yoshitaka Iwakura;Hisaya Sangawa;Yasufumi Okamura;Toshihiro Yanagi
发明人:
Toshihiro Yanagi,Yoshitaka Iwakura,Hisaya Sangawa,Yasufumi Okamura
申请号:
US13001393
公开号:
US08529953B2
申请日:
2009.06.29
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides a method for producing spherical fine particles containing tamsulosin hydrochloride, the method includes the steps of: (1) mixing and stirring tamsulosin hydrochloride (a), microcrystalline cellulose (b), and water until a mixture of the component (a) and the component (b) is uniformly impregnated with the water; (2) granulating the mixture obtained in step (1) using an stirring granulator whose peripheral speed is set to be 5.5 to 9.0 m/s; and (3) drying the granules obtained in step (2). The present invention also provides spherical fine particles obtained according to the method, coated fine particles obtained by applying a coating to the spherical fine particles, and an orally disintegrating tablet containing the coated fine particles.
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