A surgical device comprises an elongate shaft comprising a distal end and a proximal end. An actuator is operably connected to the proximal end of the elongate shaft. The actuator may be a manual handle. An end effector is adapted for in vivo attachment to and detachment from the distal end of the elongate shaft. A loader is sized to receive the end effector. A lock extends laterally from the end effector and is operative to prevent the end effector from leaving the loader. The lock may move medially relative the end effector to allow the end effector to leave the loader.
