Provided is an endoscope treatment tool including: a pair of clamp members that is supported by a clamp rotary shaft to be relatively rotatable； an operation section that is used to open and close the pair of clamp members； an operation wire that connects the pair of clamp members to the operation section； a connection member that is provided at the front end of the operation wire and includes at least one link rotary shaft； a pair of link members of which a first end is rotatably connected to each end of the pair of clamp members and a second end is rotatably connected to the link rotary shaft； and a regulation portion that regulates the connection member and the operation wire in a relative movement direction with respect to the clamp rotary shaft, wherein the connection member includes a groove formed to be parallel to the axis of the operation wire, and wherein the regulation portion engages with the groove to regulate the connection member and the operation wire in the relative movement direction.
