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Methods, systems and compositions relating to cell conversion via protein induced in-vivo cell reprogramming
专利权人:
Wayne State University;Qurgen, Inc.
发明人:
WANG, Jianjun,LI, Qianqian,CHOPP, Michael,JIANG, Feng,WU, Guojun
申请号:
AU2019204630
公开号:
AU2019204630A1
申请日:
2019.06.28
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
#$%^&*AU2019204630A120190718.pdf#####ABSTRACT Methods for treating a subject in need thereof are provided which include administering a pharmaceutical composition comprising a protein transduction reagent-modified reprogramming protein to the subject, wherein the protein transduction reagent is non-covalently bound to the reprogramming protein and wherein the protein transduction reagent comprises a cation reagent and a lipid. According to aspects, such methods provide delivery of protein-transduction reagentmodified reprogramming proteins to cancer cells, such as tumor cells, as well as diseased cells of diseased tissues and provide in vivo conversion of diseased cells into normal cells via protein-induced in situ cell reprogramming without administration of nucleic acids to the subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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