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COMPOSITIONS AND METHODS FOR USING SAME FOR REDUCING LEVELS OF ARACHIDONIC ACID IN TISSUE HAVING UNDERGONE AN INVASIVE PROCEDURE
专利权人:
PHYSICIANS RECOMMENDED NUTRICEUTICALS; LLC
发明人:
SMITH, S., Gregory,GROSS, Michael, B.
申请号:
USUS2017/039817
公开号:
WO2018/005685A1
申请日:
2017.06.28
申请国别(地区):
WO
年份:
2018
代理人:
摘要:
This invention relates to compositions for reducing levels of arachidonic acid (omega-6) found at the cellular level in tissue after surgery, wherein the composition consists of an effective amount of a single fatty acid. In certain embodiments, the composition includes omega-3 fatty acids, which may comprise the triglyceride form. The omega-3 fatty acids of the present invention may eicosapentaenoic acid (EPA) in an amount greater than 600 mg and/or docosahexaenoic acid (DHA) in an amount greater than 500 mg. In some embodiments of th present invention, the composition comprises an amount of EPA and an amount of DHA in a 3 : 1 ratio. The present invention is further directed to methods for reducing inflammation in tissue after surgery. In certain embodiments, the methods comprise the steps of: (1) administering preoperatively and/or postoperatively a composition consisting of at least one single fatty acid, wherein the single fatty acid may include omega-3 fatty acids that are in the triglyceride form, (2) increasing levels of anti-inflammatory omega-3 s in the tissue and (3) decreasing levels of inflammatory omega-6 s (arachidonic acid) in the tissue, thereby reducing post surgical inflammation by means of reducing the prostaglandin precursors and increasing the anti-inflammatory and resolvins available at the surgical site.Linvention concerne des compositions permettant de réduire les taux dacide arachidonique (oméga -6) trouvé au niveau cellulaire dans un tissu après une intervention chirurgicale, la composition étant constituée dune quantité efficace dun acide gras unique. Selon certains modes de réalisation, la composition comprend des acides gras oméga-3, qui peuvent comporter la forme triglycéride. Les acides gras oméga-3 de la présente invention peuvent être de lacide eicosapentaénoïque (EPA) en une quantité supérieure à 600 mg et/ou de lacide docosahexaénoïque (DHA) en une quantité supérieure à 500 mg. Selon certains modes de réalisation de la présente inv
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