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Positive allosteric modulators of nicotinic acetylcholine receptor
专利权人:
H. LUNDBECK A/S
发明人:
申请号:
ARP120101077
公开号:
AR085822A1
申请日:
2012.03.29
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
The present relates to compounds useful in therapy, to compositions comprising such Compounds, and Methods for the treatment of diseases that include the Administration of such compounds.The compounds referred to are positive allosteric modulators (PAMS) A7 nicotinic acetylcholine receptor play an important role in the CNS by modulating the release of neurotransmitters, involving various Cognitive functions as an Apprentice AJE, Memory and attention.Claim 1: a compound according to formula (1) wherein R1 represents h, trifluoromethyl, difluorometilo, c1-4 alkyl, alquenilo C2 - 4 or alquinilo c2-4; R2 represents h, alkyl alquenilo C1 - C2 - 4, 4, alquinilo c2-4, halogen or alkyl Ciano, where C1 alquenilo C2 - 4 - 4, or alquinil Or c2-4 is optionally substituted with one or more substituents selected from chlorine and Fluorine; R3R4, R5 and R6 are independently selected from h, c1-4 alkyl, alquenilo C2 C2 - 4 - 4, alquinilo, halogen and cyano where c1-4 alkyl, alquenilo C2 or C2 - 4 - 4 alquinilo is optionally substituted with one or more substituents selected from chlorine and Fluorine; R7 represents h, Methyl Or, trifluoromethyl or hydroxymethyl; Q represents a heteroaryl Ring with 5 ATOMS, where 12 or 3 Atoms of the Ring are selected irrespective of o, N and S, which can be optionally substituted heteroaryl said in its carbon Atoms with one or more substituents represented by R10, and if that cannot be triazolilo heteroaryl 1,2,3 or imidazolilo; each 10 is selected independently between c1-4 alkyl, alquenilo C2 - 4, alquinilo c2-4, c1-4 alkoxy,Fluoroalcoxi c1-4, halogen and OXO, where said c1-4 alkyl, alquenilo C2 or C2 - 4 - 4 alquinilo is optionally substituted with one or more Fluorine substituents selected from c1-4 alkoxy, and fluoroalcoxi c1-4; if one or more Atoms in the heteroaryl Ring Atoms n these can When Valencia allows,Be individually replaced optionally with a Substituent represented by R11, where each R11 is independently chosen between c1-4 alkyl an
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