Agency for Science, Technology and Research;Novartis AG;Beijing Institute of Microbiology and Epidemiology
发明人:
Katja Fink,Pei-Yong Shi,Cheng Feng Qin
申请号：
US14430099
公开号：
US20150231226A1
申请日:
2013.09.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2′O-methyltransferase.
