RAJAMANI, Ramkumar,RENDUCHINTALA, Kishore V.,SARKUNAM, Kandhasamy,NAGALAKSHMI, Pulicharla,MEANWELL, Nicholas A.,SCOLA, Paul Michael
申请号：
ES12729291
公开号：
ES2604690T3
申请日:
2012.06.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein q is 1 or 2； it is a single or double bond； Rp is selected from where Rp is attached to the precursor molecular moiety through any substitutable carbon atom in the group； n is 0, 1,2, 3, 4, 5 or 6； X0 is selected from CH and N； X1 is selected from CH and N； X2 and X3 are independently selected from CH, C (Ra) and N； with the proviso that at least one of X1, X2 and X3 is different from N； each Ra is independently selected from alkenyloxy, alkoxy, alkoxyalkoxy, alkyl, benzodioxanyl, carboxamido, carboxy, carboalkoxy, cyano, cycloalkylalkoxy, cycloalkyloxy, deuteroalcoxi, dialkylamino, halo, haloalkyl, haloalkoxy, haloalkoxycarbonyl, hydroxy, morpholinyl, phenyl, piperazinyl, pyrazolyl, pyridinyl and pyrrolidinyl, wherein morpholinyl, phenyl, piperazinyl, pyridinyl and pyrrolidinyl are optionally substituted with one or two groups independently selected from alkoxy, alkyl, alkylsulfonyl, halo, haloalkoxy, haloalkyl and morpholinyl； and wherein two adjacent Ra groups, together with the carbon atoms to which they are attached, can optionally form a ring selected from dioxanyl, dioxolanyl, morpholinyl, pyranyl and phenyl, wherein the ring is optionally substituted with one or two selected groups independently between alkyl and halo； Rb is alkyl； Rx is selected from methyl and ethyl； Ry and Rz are independently selected from hydrogen and hydroxy； with the proviso that when it is a double bond, Ry and Rz are each hydrogen； R2 is selected from hydrogen, alkyl, halo, haloalkoxy, haloalkyl and hydroxyalkyl； and R3 is selected from hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalcoxicarbonilo, deuterohaloalcoxicarbonilo, dialkylaminocarbonyl, dialquilaminocarbonilcarbonilo, haloalkoxycarbonyl, haloalquilaminocarbonilo, haloalkylcarbonyl, heterocyclylcarbonyl, heterocyclylox
