Paul L. HALLENBECK,Seshidhar Reddy POLICE,Laura M. HALES,Carl M. HAY,Shanthi GANESH,Ling XU,Jingping YANG,Cheng CHENG
申请号：
US14201640
公开号：
US20140348798A1
申请日:
2014.03.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.
