The present invention relates to a novel therapeutic formulation comprising an organic natural paleo probiotic prepared from Indian cow, Bos primigenius for modulating endosymbiotic archaeal growth and endogenous digoxin synthesis in the treatment of chronic diseases such as metabolic syndrome X, strokes, coronary artery disease, hyperlipidemia, diabetes mellitus, autoimmune, neuropsychiatry, neurodegenerative, cancer and infections.