The present invention relates to a combination therapy comprising selective inhibitors of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase and inhibitors of MAP kinase kinase (MEK). Accordingly, a pharmaceutical composition is provided that comprises a selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase or a pharmaceutically acceptable salt, solvate and/or hydrate thereof, and an inhibitor or a pharmaceutically acceptable salt, solvate and/or hydrate thereof, for use in medicine, especially in the treatment of cancer, like lung cancer, such as non-small cell lung cancer, lung adenocarcinoma or small cell lung cancer. Also a method for identifying patients that are particularly susceptible to such a combination therapy is subject of the present invention. The method comprises the evaluation of the expression level of VEGFR-2 and/or VEGF. An increase in said expression level indicates susceptibility to the combination therapy.
