Stephen J Savarino;Randall K Holmes;Michael G Jobling
发明人:
Stephen J Savarino,Randall K Holmes,Michael G Jobling
申请号：
US11988598
公开号：
US09107866B2
申请日:
2007.01.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.
