Described herein are materials and methods for treating subjects having a HER-3 associated disease, by administering a first agent that binds to HER-3, in combination with a second agent that binds and/or inhibits another member of the HER family. The first and the second agent may be a biologic, such as an antigen-binding protein, or a small molecular tyrosine kinase inhibitor, for example.本發明描述藉由投予第一劑與第二劑之組合以治療患有人表皮生長因子受體-3(HER-3)相關疾病之個體的藥料和方法,該第一劑與HER-3結合且該第二劑與HER家族之另一成員結合及/或抑制該成員。該第一及第二劑可能為生物製劑,諸如舉例來說抗原結合蛋白或小分子酪胺酸激酶抑制劑。
