The invention comprises a combination (1, 101) of a screw (4, 104) for a surgical application, and a driver (2, 102) for driving the screw (4, 104) for fastening orthopaedic Implants either to bone or to an orthopaedic implant in particular a dental component to a dental implant is proposed, the screw (4, 104) having a first end (3) and an apical end (5), a head (10) at its first end (3) and a thread (13) at its apical end (5), a bore (12, 112) running axially from the first end (3) of the screw along a portion of the screw (4, 104) towards the apical end (5) of the screw (4, 104), a first zone (7, 107) at the first end (3) of the bore (12, 112) and a second zone (9, 109) at the apical end of the bore (12, 112), the first zone (7, 107) of the bore (12, 112) comprises clipping means (20, 120) and the second zone of the bore comprises peripheral engagement means (14, 114); the driver (2, 102) comprises a driver head (6, 106) having a first (16, 116) and a second segment (17, 117), the first segment (16, 116) comprises means (19) for triggering the clipping means (20, 120) in the first zone (7, 107) of the bore (12, 112) during the axial insertion of the driver head (6, 106) into the bore (12, 112) so as to maintain the screw (4, 104) releasably fastened to the driver (2, 102); the second segment (17, 117) comprises means for engaging the peripheral engagement means (14, 114) in the second zone (9, 109) at the apical end of the bore (12, 112) for the transmission of a couple to fasten or loosen the screw (4, 104), wherein the second segment (17, 117) of the driver head (6, 106) has a substantially rounded axial section, and the second zone (9, 109) of the bore (12, 112) has a rounded socket shape adapted to engage with the second segment (17, 117) of the driver head (6, 106) in various angled positions of the driver (2, 102) versus the axial direction of the screw (4, 104).