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LIQUID VACCINES FOR MULTIPLE MENINGOCOCCAL SEROGROUPS
专利权人:
NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.
发明人:
CONTORNI, MARIO
申请号:
CA2885040
公开号:
CA2885040C
申请日:
2004.10.04
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
An aqueous immunogenic composition which, after administration to a subject, is able to induce an immune response that is (a) bactericidal against at least serogroup W135 of N.meningitidis and (b) protective against H influenzae type b disease, wherein the composition comprises: (i) a conjugated serogroup W135 capsular saccharide antigen and (ii) a conjugated H influenzae type b (Hib) capsular saccharide antigen. The conjugated serogroup W135 saccharide may be conjugated, for example, to a diphtheria toxoid, a tetanus toxoid, a H.influenzae protein D, a tetanus toxoid, and may include an aluminium phosphate adjuvant. The conjugated serogroup W135 saccharide may be conjugated to a CRM197 diphtheria toxin mutant, the composition comprising < 30 µg meningococcal saccharide per dose.
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