COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS
INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOSUN UNIVERSITY
发明人:
OH, WON KEUN,NGUYEN, PHI HUNG,LE, THI VAN THU,KANG, HU WON,SHIN, EUI SEOK,CHIO, JIN KYU,SEO, DAE BANG,LEE, SANG JUN
申请号：
EP09845576
公开号：
EP2438923A4
申请日:
2009.06.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan compound which activates nutmeg-derived AMP-activated protein kinase (AMPK), and to a composition including same as active ingredients for preventing and treating metabolic syndromes such as obesity. More particularly, the present invention relates to an AMPK-activating compound comprising one of the 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan-based compounds produced by extracting Myristica fragrans with a solution of 30% or less of ethanol and separating and purifying the extracts using chromatography, as expressed in chemical formula 1 below, and to a composition comprising same as an active ingredient for preventing and treating metabolic syndrome caused by AMPK enzyme activation, such as obesity, diabetes, high cholesterol and cardiopulmonary diseases.
