STABLE WATER ISOTOPE LABELING AND MAGNETIC RESONANCE IMAGING FOR VISUALIZATION OF RAPIDLY DIVIDING CELLS

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专利权人:

Nataliya BUXBAUM;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

发明人:

Nataliya BUXBAUM,Donald FARTHING,Martin LIZAK,Helmut MERKLE,Natella MAGLAKELIDZE,Brittany OLIVER,Ronald GRESS

申请号：

US16345612

公开号：

US20190274616A1

申请日:

2017.10.27

申请国别(地区):

US

年份:

2019

代理人:

摘要：

This disclosure generally relates to stable water isotope labeling followed by detection via MRI (swiMRI), including deuterium MRI (dMRI) and 17O MRI, for visualizing rapidly dividing immune cells within target and/or lymphoid organ/s and/or tissues affected by chronic graft-versus-host disease (cGVHD). Using deuterated water labeling, followed by dMRI, a distinction in deuterium signal was detected in a target organ (e.g. liver) of the cGVHD-affected mice compared to unaffected mice, i.e. syngeneic HSCT recipient mice, where the host and donor are matched, and normal (unmanipulated) mice.

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