COE JOTHAM WADSWORTH,JONES PETER,SABNIS YOGESH ANIL,STROHBACH JOSEPH WALTER,WAKENHUT FLORIAN MICHEL,WHITLOCK GAVIN ALISTAIR,DEHNHARDT CHRISTOPH MARTIN
申请号：
AP2016009562
公开号：
AP2016009562A0
申请日:
2015.04.30
申请国别(地区):
AP
年份:
2016
代理人:
摘要：
A compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A and A&prime； are independently C or N, where C may be unsubstituted or substituted by halo or C1-C6 alkyl； R and R0 are independently selected from the group consisting of H, C1-C6 alkyl, hydroxy(C1-C6 alkyl), phenyl(C1-C6 alkyl), and &mdash；(CH2)n&mdash；W, where W is C3-C8 cycloalkyl, phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing 1-3 N, S and/or O atoms, &mdash；SO2&mdash；R&prime；, &mdash；NHSO2&mdash；R&prime；, &mdash；NR&Prime；SO2&mdash；R&prime； and SR&prime；, where R&prime； and R&Prime； are independently C1-C6 alkyl or C3-C8 cycloalkyl, etc.； wherein each of said alkyl, cycloalkyl, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, heteroaryl, etc.； or, R and R0 and the N atom to which they are bonded together form a monocyclic or bicyclic heterocyclic ring which may be unsubstituted or substituted by (a) halo, hydroxy, heteroaryl, C1-C6 alkyl, C1-C6 alkoxy, etc., or (b) &mdash；(CH2)n&mdash；W, where W is C3-C8 cycloalkyl, phenyl, etc.； R1 is H, halo or cyano； R2 and R2&prime； are independently H, C1-C6 alkyl, cyano, C1-C6 alkoxy, C1-C6 alkylthio, or C3-C8 cycloalkyl where alkyl, alkoxy, or cycloalkyl is optionally substituted by one or more fluorine atoms； X is a bond, &mdash；CO&mdash；, &mdash；CONH&mdash；, &mdash；SO2&mdash；, &mdash；SONH&mdash；, or &mdash；(CH2)m&mdash；； R3 is H, C1-C4 alkyl, phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing 1-3 N atoms, a 5-membered heteroaryl or heterocyclic, etc., or (c) 2 O or S atoms and 0-2 N atoms； wherein each of said phenyl, naphthyl, heteroaryl or heterocyclic is optionally substituted by alkyl, 1 substituent &mdash；Y&mdash；R4 and/or 1-4 substituents each independently selected from R5； with the proviso that when X is &mdash；CO&mdash； or &mdash；SO2&mdash
